Dec 03, 2023
CHEM 5810 - Medicinal Chemistry and Drug Discovery
This course focuses on the chemical principles involved in small molecule drug discovery, design and development. The organic chemistry of drug design and drug action is studied in detail. Starting from strategies for finding a lead compound through optimizing target interactions and drug efficacy, to ultimately bringing the drug to market, the impact of each step on the drug design process is discussed. Drug design tools and approaches such as combinatorial chemistry, molecular modeling, structure-activity-relationships and other strategies are analyzed in detail along with selected topics in the medicinal chemistry of both classic therapeutic agents and newer therapeutic breakthroughs.
Credit Hours: 4
Repeat/Retake Information: May not be retaken.
Lecture/Lab Hours: 4.0 lecture
Grades: Eligible Grades: A-F,WP,WF,WN,FN,AU,I
- Students will be able to use technology to identify the most prevalent types of molecular interactions that occur with common drug target classes.
- Students will be able to describe strategies for drug lead identification.
- Students will be able to propose strategies for optimizing drug-target interactions and access.
- Students will be able to identify select classes of drugs and describe the biochemical mechanism of action by which they function.
- Students will be able to identify and discuss the challenges of drug discovery for orphan and neglected diseases.
- Students will be able to discuss the drug-to-market approval process and the impact that market demand (and monopolies) have on drug design & discovery focus.
- Students will be able to utilize molecular visualization software to aid in drug design.
- Students will be able to propose a new drug using the design strategies discussed in the class and be able to defend their design in a written research proposal.
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